Real Madrid set out to prove their Champions League dominance is not dependant on Cristiano Ronaldo when Roma visit the Santiago Bernabeu on Wednesday.
The holders were dumped out in the Round of 16 the last time they commenced a campaign without the 33-year-old, whose hopes of inspiring Juventus to success get an early test away to Valencia.
Both Manchester clubs are involved on the same day as City meet Lyon for the first time and United, away to Young Boys, attempt to reverse a poor recent record in Switzerland.
Meanwhile, in Portugal, Bayern Munich will look to prolong Benfica s long wait for a drought-breaking Champions League result.
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